Description

S-Chloromethylglutathione is a chemically modified derivative of the essential tripeptide glutathione, designed for advanced biochemical research and synthesis. This compound serves as a critical intermediate for the development of novel enzyme inhibitors, targeted prodrugs, and molecular probes used in studying cellular redox mechanisms. It is particularly valuable for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity, specialized building blocks for drug discovery and biochemical assay development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates targeting glutathione-S-transferase (GST) enzymes.
• Biochemical Research: Used as a substrate analog or an active-site directed inhibitor in enzymatic studies of glutathione metabolism and detoxification pathways.
• Proteomics & Molecular Biology: Employed for the selective modification of cysteine residues in proteins and peptides to study structure-function relationships.
• Prodrug Development: Serves as a versatile linker or carrier moiety in the design of targeted prodrug systems for enhanced drug delivery and reduced toxicity.
• Diagnostic Reagent Synthesis: Intermediate in the production of specialized reagents and fluorescent probes for cellular imaging and diagnostic assays.
• Antioxidant Research: Tool compound for investigating the role of glutathione and its analogs in oxidative stress and related disease models.

Basic Information

Product Name	S-Chloromethylglutathione
CAS No.	150956-90-4
Molecular Formula	C11H18ClN3O6S
Molecular Weight	355.79 g/mol
Synonyms	L-Glutathione, S-(chloromethyl)-; S-(Chloromethyl)glutathione; Chloromethyl Glutathione; γ-Glutamyl-S-(chloromethyl)cysteinylglycine; NSC 339586; Glutathione S-(chloromethyl) derivative; (2S)-2-Amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-[(chloromethyl)sulfanyl]ethyl]carbamoyl}butanoic acid
EINECS	Contact for details

Quality Control

Our S-Chloromethylglutathione is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Our quality commitment supports reliable and reproducible results in your most critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.