Description

n-Iodoacetyl-3-Iodotyrosine is a specialized, bifunctional chemical reagent featuring both an iodoacetyl group and an iodinated aromatic ring. This compound is a critical building block in bioconjugation chemistry, enabling the site-specific labeling and crosslinking of biomolecules under controlled conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing targeted therapeutics, advanced imaging probes, and sensitive assay systems.

Application

• Bioconjugation Reagent: For the site-specific modification of peptides, proteins, and antibodies via thiol- or amine-reactive chemistry.
• Radiopharmaceutical Precursor: Acts as an intermediate in the synthesis of radioiodinated compounds for diagnostic imaging (e.g., SPECT) and targeted radiotherapy.
• Proteomics Research: Used in activity-based protein profiling (ABPP) and chemical proteomics to study enzyme function and discover new drug targets.
• Crosslinking Agent: Facilitates the creation of stable covalent bonds between biomolecules for studying protein-protein interactions or creating immobilized enzyme systems.
• Fluorescent Probe Synthesis: Serves as a key intermediate for attaching fluorophores to biomolecules for cellular imaging and flow cytometry applications.
• Antibody-Drug Conjugate (ADC) Development: Enables the precise attachment of cytotoxic payloads to monoclonal antibodies for next-generation cancer therapies.

Basic Information

Product Name	n-Iodoacetyl-3-Iodotyrosine
CAS No.	150956-52-8
Molecular Formula	C11H9I2NO4
Molecular Weight	488.99 g/mol
Synonyms	N-Iodoacetyl-3-iodo-L-tyrosine; 3-Iodo-N-(iodoacetyl)-L-tyrosine; Iodoacetyl-3-iodotyrosine; L-Tyrosine, 3-iodo-N-(iodoacetyl)-; (2S)-2-[(2-Iodoacetyl)amino]-3-(4-hydroxy-3-iodophenyl)propanoic acid; N-(Iodoacetyl)-3-iodo-L-tyrosine; Bioconjugation Reagent 150956-52-8
EINECS	Contact for details

Quality Control

Our n-Iodoacetyl-3-Iodotyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere for long-term stability. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.