Description

(D-Thr6,D-Trp8,9,L-Alaninol15)-Galanin (1-15) CAS NO 150940-97-9 is a synthetic, modified peptide analog of the neuropeptide galanin, designed for enhanced stability and receptor interaction. This compound is critical for advanced research in neurobiology and pharmacology, serving as a potent and selective tool for studying galanin receptor signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for neurological disorders, pain management, and metabolic diseases.

Application

• Neuroscience Research: A key tool for investigating the role of galanin in the central and peripheral nervous system, including studies on pain modulation, cognition, and feeding behavior.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening (HTS) assays to identify and characterize new galanin receptor agonists or antagonists.
• Receptor Binding Studies: Essential for competitive binding assays (e.g., radioligand binding) to determine receptor affinity (Ki/IC50 values) and selectivity for GalR1, GalR2, and GalR3 receptor subtypes.
• Signal Transduction Analysis: Employed in functional assays to study downstream cellular effects, such as cAMP inhibition or MAPK/ERK pathway activation.
• Biochemical Reagent: Serves as a critical component in the development of diagnostic kits and research reagents for neurological and endocrine research.
• Preclinical Studies: Used in animal models to evaluate the therapeutic potential of galanin pathway modulation for conditions like epilepsy, depression, and diabetes.

Basic Information

Product Name	(D-Thr6,D-Trp8,9,L-Alaninol15)-Galanin (1-15)
CAS No.	150940-97-9
Molecular Formula	C78H115N23O21S
Molecular Weight	1747.0 g/mol
Synonyms	Galanin (1-15) analog; [D-Thr6, D-Trp8,9, L-Alaninol15]-Galanin(1-15); Galanin-like peptide (modified); Galanin receptor ligand; M871 (common research alias); Galanin (1-15) amide derivative; Galanin fragment 1-15 analog; Selective galanin receptor antagonist (context-dependent)
EINECS	Contact for details

Quality Control

Every batch of (D-Thr6,D-Trp8,9,L-Alaninol15)-Galanin (1-15) is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. Certificates of Analysis (COA) detailing HPLC purity, amino acid analysis, mass spectrometry (MS) confirmation, and endotoxin levels are available for each lot. Our quality commitment aligns with standards expected for pharmaceutical-grade research peptides.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate under inert atmosphere or vacuum. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass confirmed by ESI-TOF or MALDI-TOF
Purity (HPLC)	≥ 95% (Area percent at 214 nm)
Assay (Peptide Content)	≥ 80% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.