Description

L-Threonine, 4-Fluoro-, Ethyl Ester (9Ci) is a fluorinated derivative of the amino acid threonine, where the hydroxyl group is replaced by fluorine and the carboxylic acid is protected as an ethyl ester. This specific structural modification makes it a valuable non-natural amino acid building block for advanced research and synthesis. It is primarily utilized in the development of novel pharmaceuticals, bioactive peptides, and complex organic molecules. This compound is of significant interest to researchers and process chemists in the pharmaceutical, agrochemical, and life science industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, including protease inhibitors and metabolic modulators.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a fluorinated threonine residue, altering the peptide's stability, bioavailability, and biological activity.
• Medicinal Chemistry Research: Serves as a crucial building block for structure-activity relationship (SAR) studies to explore the effects of fluorine substitution on molecular properties.
• Agrochemical Development: Potential intermediate in the synthesis of novel fluorinated pesticides or herbicides, leveraging fluorine's ability to enhance metabolic stability and membrane permeability.
• Biochemical Probe Development: Used to create labeled analogs or probes for studying enzyme mechanisms and protein interactions where the native hydroxyl group of threonine is involved.
• Organic Synthesis: Acts as a versatile chiral starting material for the asymmetric synthesis of more complex, fluorinated organic compounds.

Basic Information

Product Name	L-Threonine, 4-Fluoro-, Ethyl Ester (9Ci)
CAS No.	150672-39-2
Molecular Formula	C6H12FNO3
Molecular Weight	165.16 g/mol
Synonyms	L-4-Fluorothreonine Ethyl Ester; (2S,3S)-2-Amino-3-fluoro-4-ethoxy-4-oxobutanoic Acid; Ethyl L-4-fluorothreoninate; 4-Fluoro-L-threonine Ethyl Ester; (2S,3S)-4-Fluorothreonine Ethyl Ester; F-Thr-OEt; 4-F-Thr-OEt; 150672-39-2
EINECS	Contact for details

Quality Control

Our L-Threonine, 4-Fluoro-, Ethyl Ester (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure identity, strength, and purity. We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable and consistent material for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.