Description

Fmoc-L-Lys(Nvoc)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in enabling complex, multi-step peptide assembly by providing selective deprotection strategies, which is essential for synthesizing challenging sequences and modified peptides. It is primarily needed by research institutions, pharmaceutical R&D departments, and CROs/CMOs focused on developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of peptides, particularly those requiring orthogonal protection schemes.
• Synthesis of Modified Peptides: Enables the site-specific incorporation of functional groups or labels onto lysine side chains during peptide chain elongation.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, hormones, and vaccine candidates that require precise chemical structures.
• Bioconjugation and Probe Development: Serves as a precursor for creating peptide-based imaging agents, affinity tags, and diagnostic probes.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic Research: A vital tool for studying protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR) in biochemistry and chemical biology.

Basic Information

Product Name	Fmoc-L-Lys(Nvoc)-Oh
CAS No.	150571-28-1
Molecular Formula	C₃₁H₃₁N₃O₇
Molecular Weight	557.60 g/mol
Synonyms	Fmoc-Lys(Nvoc)-OH; N-α-Fmoc-N-ε-(6-nitroveratryloxycarbonyl)-L-lysine; Fmoc-Lys(Nvoc)-OH; (2S)-6-[[(6-Nitro-1,3-benzodioxol-5-yl)oxy]carbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; N-α-(9-Fluorenylmethyloxycarbonyl)-N-ε-(6-nitroveratryloxycarbonyl)-L-lysine; Fmoc-Lys(Nvoc)-OH (SPPS grade); Orthogonally protected Fmoc-Lysine derivative
EINECS	Contact for details

Quality Control

Our Fmoc-L-Lys(Nvoc)-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to maintain stability and prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.