Description

Rumbrin is a high-purity specialty chemical identified by CAS NO 150206-14-7, widely utilized in advanced pharmaceutical research and development. It serves as a critical intermediate or reference standard in the synthesis and analytical validation of bioactive compounds, offering exceptional batch-to-batch consistency and traceability. Pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and quality control units in global API manufacturers rely on Rumbrin for method development, stability studies, and impurity profiling.

Application

• Pharmaceutical reference standard for HPLC and LC-MS calibration in API purity testing
• Key synthetic intermediate in the development of kinase inhibitors and antineoplastic agents
• Stability-indicating assay component for forced degradation studies (oxidative, hydrolytic, photolytic)
• Matrix-matched standard in bioanalytical method validation for preclinical pharmacokinetic studies
• Raw material in GMP-compliant small-molecule drug substance manufacturing
• Control standard for genotoxic impurity (GTI) risk assessment workflows
• Calibration material in regulatory submissions to FDA, EMA, and PMDA
• Research tool in structure–activity relationship (SAR) studies targeting epigenetic modulators

Basic Information

Product Name	Rumbrin
CAS No.	150206-14-7
Molecular Formula	C21H20N2O4
Molecular Weight	364.40 g/mol
Synonyms	Rumbrin; 150206-14-7; (2R,3R)-2-(4-Hydroxyphenyl)-3-(4-methoxyphenyl)-2,3-dihydro-1H-indol-1-one; Indolinone derivative; NSC 726185; BRD-K92112345; AKOS025956512; Z1122272118; 2,3-Dihydro-1H-indol-1-one, 2-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-, (2R,3R)-
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q2(R2) guidelines and conform to applicable sections of USP <1058>, EP 2.2.46, and ISO/IEC 17025. Testing includes identity confirmation (IR, NMR), assay (HPLC), residual solvents (GC), heavy metals (ICP-MS), and microbiological limits where relevant. Grade-specific certifications—including ISO 9001, ISO 14001, and REACH compliance documentation—are provided for commercial orders.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccant-containing secondary packaging during long-term storage. Avoid repeated opening of primary container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 99.5%
Related Substances (HPLC)	Single impurity ≤ 0.1%; Total impurities ≤ 0.5%
Loss on Drying	≤ 0.5% (at 105°C for 2 hours)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.