Description

L-Serine-1,2-13C2 is a stable isotope-labeled analog of the essential amino acid L-serine, specifically enriched with carbon-13 at the 1 and 2 positions. This compound is a critical tool for advanced research and development, enabling precise metabolic pathway tracing and quantitative analysis in complex biological systems. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in drug metabolism studies, proteomics, and clinical diagnostics.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study central carbon metabolism, glycolysis, and serine biosynthesis pathways in cell cultures and model organisms.
• Drug Development & Pharmacokinetics (PK/PD): Serves as an internal standard in mass spectrometry for the accurate quantification of serine and related metabolites in biofluids during drug metabolism studies.
• Proteomics & Protein Labeling: Employed in stable isotope labeling by amino acids in cell culture (SILAC) for quantitative proteomic analysis to measure protein expression and turnover.
• Clinical Research & Diagnostics: Facilitates research into metabolic disorders, cancer metabolism, and neurological diseases where serine metabolism is implicated.
• NMR Spectroscopy: Provides a sensitive probe for structural and dynamic studies of proteins and enzymes due to the distinct magnetic properties of the 13C nuclei.
• Biochemical Research: Acts as a precursor in the study of phospholipid and nucleotide synthesis, as well as one-carbon metabolism.

Basic Information

Product Name	L-Serine-1,2-13C2
CAS No.	150146-96-6
Molecular Formula	C13H713C1H3NO3 or C3H7NO3 (with 13C at positions 1 & 2)
Molecular Weight	107.1 g/mol (approx., for labeled form)
Synonyms	(2S)-2-Amino-3-hydroxy(1,2-13C2)propanoic acid; L-(1,2-13C2)Serine; Serine-1,2-13C2; (S)-Serine-1,2-13C2; 13C Labeled L-Serine; L-Serine (1,2-13C2); Stable Isotope Labeled L-Serine; 13C2-L-Serine
EINECS	Contact for details

Quality Control

Every batch of our L-Serine-1,2-13C2 is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for research applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity, and specific analytical data from techniques such as NMR, HPLC, and MS. Our quality commitment aligns with the standards required for pharmaceutical and advanced biomedical research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99% at positions 1 & 2
Optical Rotation	[α]20/D: +13.5° to +15.5° (c=1 in H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.