Description

Nw-Hydroxyl-L-Arginine Dihydrochloride is a high-purity, modified amino acid derivative of L-Arginine, featuring a hydroxyl group on the terminal nitrogen of the guanidino side chain. This specific modification is crucial for advanced biochemical research and pharmaceutical development, particularly in the study of nitric oxide synthase (NOS) inhibition and related metabolic pathways. It serves as a critical building block and reference standard for researchers and manufacturers in the life sciences sector. The compound is supplied as a dihydrochloride salt to enhance its stability and solubility for experimental and formulation purposes.

Application

• Biochemical Research: A key intermediate and reference standard in enzymatic studies, particularly for investigating nitric oxide synthase (NOS) activity, inhibition mechanisms, and urea cycle metabolism.
• Pharmaceutical R&D: Serves as a precursor or active pharmaceutical ingredient (API) intermediate in the development of novel therapeutics targeting cardiovascular diseases, neurological disorders, and immune modulation.
• Peptide Synthesis: Used as a specialized, protected arginine analog in solid-phase and solution-phase peptide synthesis to introduce modified functionalities into peptide chains.
• Diagnostic Reagents: Employed in the formulation of diagnostic kits and assays designed to measure NOS activity or related biomarkers in clinical and research settings.
• Cell Culture & Microbiology: Acts as a component of specialized cell culture media for studying amino acid metabolism and cellular signaling pathways in vitro.

Basic Information

Product Name	Nw-Hydroxyl-L-Arginine Dihydrochloride
CAS No.	149971-04-0
Molecular Formula	C6H16Cl2N4O3
Molecular Weight	263.12 g/mol
Synonyms	Nω-Hydroxy-L-arginine dihydrochloride; NG-Hydroxy-L-arginine dihydrochloride; L-Nω-Hydroxyarginine dihydrochloride; (2S)-2-Amino-5-[(amino-hydroxyamino)methylideneamino]pentanoic acid dihydrochloride; NOHA dihydrochloride; N-Hydroxyarginine dihydrochloride; H-Arg(NOH)-OH·2HCl
EINECS	Contact for details

Quality Control

Our Nw-Hydroxyl-L-Arginine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We support compliance with relevant guidelines for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.