Description

4-Pyrimidinecarbonyl Chloride, 2-Chloro- (9Ci) is a highly reactive and versatile heterocyclic acid chloride building block, essential for the synthesis of complex pharmaceutical intermediates and agrochemicals. Its core value lies in enabling the efficient introduction of the 2-chloro-4-pyrimidinecarbonyl moiety, a key structural motif in active compounds. This product is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used to construct pyrimidine-based herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or cross-linking agent for creating novel polymers and functional materials with specific properties.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-organic frameworks (MOFs) or catalysts for organic transformations.
• Custom Synthesis and Contract Manufacturing: A key building block for custom chemical synthesis services targeting novel chemical entities.
• Bioconjugation Chemistry: Can be used to attach pyrimidine derivatives to biomolecules like peptides or proteins for research purposes.

Basic Information

Product Name	4-Pyrimidinecarbonyl Chloride, 2-Chloro- (9Ci)
CAS No.	149849-93-4
Molecular Formula	C5H2Cl2N2O
Molecular Weight	176.99 g/mol
Synonyms	2-Chloropyrimidine-4-carbonyl chloride; 2-Chloro-4-pyrimidinecarbonyl chloride; 2-Chloropyrimidine-4-carboxylic acid chloride; 4-Pyrimidinecarbonyl chloride, 2-chloro-; 2-Chloro-4-(chlorocarbonyl)pyrimidine; 2-Chloropyrimidine-4-carboxyl chloride; 2-Chloroisonicotinoyl chloride (related); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4-Pyrimidinecarbonyl Chloride, 2-Chloro- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.