Description

2-Chloropyrimidine-4-Carboxylic Acid is a versatile and high-value heterocyclic building block essential for advanced organic synthesis. Its core value lies in its bifunctional reactivity, where the carboxylic acid and chlorinated pyrimidine moieties serve as distinct handles for constructing complex molecular architectures. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyrimidine core's bioactivity.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and functional polymers due to its conjugated system.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & R&D Laboratories: Used in medicinal chemistry programs and methodological research for exploring new C-C and C-N bond-forming reactions.

Basic Information

Product Name	2-Chloropyrimidine-4-Carboxylic Acid
CAS No.	149849-92-3
Molecular Formula	C5H3ClN2O2
Molecular Weight	158.54 g/mol
Synonyms	4-Pyrimidinecarboxylic acid, 2-chloro-; 2-Chloro-4-pyrimidinecarboxylic acid; 2-Chloropyrimidine-4-carboxylic acid; 2-Chloro-1,3-diazine-4-carboxylic acid; 2-Chloro-4-carboxypyrimidine; 149849-92-3; 2-Chloro-4-pyrimidine carboxylic acid; 2-Chloropyrimidine-4-carboxylate
EINECS	Contact for details

Quality Control

Our 2-Chloropyrimidine-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.