Description

(-)-(2S,5R)-9-[2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]Guanine is a high-purity, stereochemically defined nucleoside analogue. This compound is a critical chiral intermediate and reference standard in the research and development of antiviral pharmaceuticals. It is essential for pharmaceutical companies, research institutions, and CDMOs focused on nucleoside chemistry and antiviral drug discovery. The product is supplied under strict quality control to ensure batch-to-batch consistency for demanding applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel antiviral agents and nucleoside-based therapeutics.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical manufacturing (GMP/GLP environments).
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to viral replication mechanisms.
• Antiviral Drug Discovery: A core scaffold for structure-activity relationship (SAR) studies to develop new treatments for viral infections.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Academic Research: Employed in university and institutional labs for fundamental studies in medicinal chemistry and virology.

Basic Information

Product Name	(-)-(2S,5R)-9-[2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]Guanine
CAS No.	149819-75-0
Molecular Formula	C9H11N5O3S
Molecular Weight	269.28 g/mol
Synonyms	(-)-2'-Deoxy-3'-thiacytidine related compound; (2S,5R)-9-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]guanine; Lamivudine Impurity; 3TC Impurity; BCH-189 related compound; (-)-β-L-2',3'-Dideoxy-3'-thiacytidine impurity; Oxathiolanyl guanine derivative; L-Oxathiolane guanine
EINECS	Contact for details

Quality Control

Our (-)-(2S,5R)-9-[2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl]Guanine is manufactured under a quality management system. Each batch is subjected to rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.