Description

H-Pro-Phe-Me Trifluoroacetate is a high-purity, non-natural dipeptide derivative used extensively in advanced pharmaceutical research and development. This compound serves as a critical building block and chiral intermediate for the synthesis of complex peptide-based therapeutics and active pharmaceutical ingredients (APIs). It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality raw materials for drug discovery, process development, and scale-up production.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide drugs and protease inhibitors.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and proteomics research.
• Peptide Library Construction: Serves as a specialized building block in combinatorial chemistry for generating diverse peptide libraries for screening.
• API Development: Employed in the research and process development of new Active Pharmaceutical Ingredients (APIs), particularly in oncology and metabolic disease areas.
• Fine Chemical Synthesis: A valuable intermediate for custom synthesis and contract manufacturing of complex organic molecules.

Basic Information

Product Name	H-Pro-Phe-Me Trifluoroacetate
CAS No.	149673-08-5
Molecular Formula	C17H21N3O5 • C2HF3O2
Molecular Weight	Contact for details
Synonyms	L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, methyl ester, trifluoroacetate; Z-Pro-Phe-NHMe TFA; Cbz-Pro-Phe-NHMe TFA; N-Carbobenzoxy-L-prolyl-L-phenylalanine methylamide trifluoroacetate; Nα-Cbz-L-Prolyl-L-phenylalanine N-methylamide TFA salt; Methyl N-[(benzyloxy)carbonyl]-L-prolyl-L-phenylalaninate trifluoroacetate; Z-L-Pro-L-Phe-NHMe • CF3COOH
EINECS	Contact for details

Quality Control

Our H-Pro-Phe-Me Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.