Description

Iefradafiban CAS NO 149503-79-7 is a potent and selective non-peptide glycoprotein IIb/IIIa (GP IIb/IIIa) receptor antagonist. This compound is of significant interest in pharmaceutical research and development for its antiplatelet and antithrombotic properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular drug discovery and the development of novel therapeutic agents for thrombosis and related disorders.

Application

• Pharmaceutical Research & Development (R&D): Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of antiplatelet medications.
• Cardiovascular Pharmacology Studies: Used in in vitro and in vivo research to investigate mechanisms of platelet aggregation inhibition and arterial thrombosis.
• Biochemical Assay Development: Employed as a ligand in assays designed to screen for and characterize new GP IIb/IIIa receptor antagonists.
• Metabolism and Pharmacokinetics (PK/PD) Studies: Utilized as a standard in analytical method development for quantifying drug levels in biological matrices.
• Academic Research: Supports fundamental scientific studies in hematology, vascular biology, and signal transduction pathways related to platelet activation.

Basic Information

Product Name	Iefradafiban
CAS No.	149503-79-7
Molecular Formula	C20H22N4O3S
Molecular Weight	398.48 g/mol
Synonyms	Iefradafiban; Ro 44-9883; L-738,167; 4-[[4-(Aminoiminomethyl)phenyl]amino]-1,4-dihydro-1-[2-(4-hydroxyphenyl)ethyl]-5H-tetrazol-5-one; 4-[[4-(Carbamimidoyl)phenyl]amino]-1-[2-(4-hydroxyphenyl)ethyl]-1,4-dihydro-5H-tetrazol-5-one; 4-[[4-(Aminoiminomethyl)phenyl]amino]-1-[2-(4-hydroxyphenyl)ethyl]-1,4-dihydro-5H-tetrazol-5-one; GP IIb/IIIa antagonist Ro 44-9883
EINECS	Contact for details

Quality Control

Our Iefradafiban is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our commitment to supplying reliable and well-characterized research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.