Description

Bombesin (6-13), Tyr(6) Methyl Ester is a bioactive peptide fragment derived from the C-terminal region of the bombesin peptide. This compound is a crucial research tool for studying the role and signaling pathways of gastrin-releasing peptide (GRP) receptors in mammalian systems. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neurobiology, oncology, and metabolic disorder research.

Application

• Neuroscience Research: Used as a specific ligand to investigate the function of GRP receptors in the central and peripheral nervous systems.
• Oncology Studies: Employed in cancer research to explore the role of bombesin-like peptides and their receptors in tumor growth and proliferation, particularly in prostate, breast, and lung cancers.
• Biochemical Assay Development: Serves as a standard or reference compound in the development of receptor binding assays, radioimmunoassays (RIA), and other in vitro diagnostic tests.
• Signal Transduction Research: A key tool for studying intracellular signaling cascades, such as calcium mobilization and MAPK/ERK pathways, activated by GRP receptor binding.
• Peptide Chemistry & Drug Discovery: Used as a starting material or intermediate for the synthesis of novel peptide analogs and potential therapeutic agents targeting bombesin receptors.

Basic Information

Product Name	Bombesin (6-13), Tyr(6) Methyl Ester
CAS No.	149440-24-4
Molecular Formula	C46H68N14O12
Molecular Weight	985.1 g/mol
Synonyms	Tyr(6)-Bombesin(6-13) Methyl Ester; [Tyr6]-Bombesin (6-13) Methyl Ester; Bombesin Fragment 6-13, Tyr(6) Methyl Ester; GRP (18-25), Tyr(4) Methyl Ester; H-Gln-Trp-Ala-Val-Gly-His-Tyr(OMe)-Leu-Met-NH2; L-Methioninamide, N-[N-[N-[N2-[N-[N-[N-(N-L-glutaminyl-L-tryptophyl)-L-alanyl]-L-valyl]glycyl]-L-histidyl]-O-methyl-L-tyrosyl]-L-leucyl]-
EINECS	Contact for details

Quality Control

Our Bombesin (6-13), Tyr(6) Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Composition	± 10% of theoretical
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 70.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.