Description

N,S-Bis-Fmoc-Glutathione is a protected derivative of the essential tripeptide antioxidant glutathione, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise, high-yield incorporation of glutathione into synthetic peptide chains while preventing unwanted side reactions. It is primarily utilized in the pharmaceutical, biotechnology, and advanced research sectors for the development of novel therapeutic peptides, biochemical probes, and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key building block for the controlled introduction of glutathione sequences into custom peptides.
• Pharmaceutical R&D: Used in the research and development of peptide-based drugs targeting oxidative stress, such as potential treatments for neurodegenerative diseases and cancer.
• Bioconjugation and Probe Development: Enables the site-specific labeling or functionalization of peptides and proteins for imaging, diagnostic, or targeting applications.
• Biochemical Research: A fundamental reagent for studying glutathione's role in redox biology, enzyme function, and cellular signaling pathways.
• Production of Glutathione Analogues: Facilitates the synthesis of modified glutathione peptides with enhanced stability, activity, or specificity for research purposes.

Basic Information

Product Name	N,S-Bis-Fmoc-Glutathione
CAS No.	149438-56-2
Molecular Formula	C39H38N4O10S
Molecular Weight	754.81 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(9H-fluoren-9-ylmethoxy)carbonyl]glutathione; Bis-Fmoc-Glutathione; Fmoc-Gly-Cys(Fmoc)-Glu-OH; γ-L-Glutamyl-L-cysteinylglycine N,S-bis(9-fluorenylmethyl) carbamate; Glutathione, N,S-bis(9H-fluoren-9-ylmethoxycarbonyl)-; N,S-Di-Fmoc-glutathione; Fmoc-GSH(Fmoc); L-γ-Glutamyl-L-cysteinylglycine N,S-bis-Fmoc
EINECS	Contact for details

Quality Control

Our N,S-Bis-Fmoc-Glutathione is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for peptide synthesis building blocks, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.