Description

2-Methylmalonoyl Carnitine is a specialized acylcarnitine derivative, a key intermediate in mitochondrial fatty acid and branched-chain amino acid metabolism. Its precise quantification is critical for research into inborn errors of metabolism and the development of advanced diagnostic assays. This high-purity biochemical is essential for laboratories in the pharmaceutical, clinical diagnostics, and life science research sectors requiring reliable reference standards and analytical reagents.

Application

• Biomarker Research & Diagnostic Assay Development: Serves as a critical reference standard for the accurate quantification of acylcarnitine profiles in plasma and dried blood spots, vital for newborn screening and metabolic disorder diagnosis.
• Inborn Errors of Metabolism (IEM) Studies: Used as an analytical standard in research focused on disorders like methylmalonic acidemia and propionic acidemia to understand metabolic flux and pathophysiology.
• Mass Spectrometry Calibration: An essential calibrant and internal standard for LC-MS/MS and GC-MS methods in clinical and research metabolomics laboratories.
• Pharmaceutical R&D: Employed in drug discovery and development programs targeting mitochondrial function and metabolic pathways.
• Nutritional & Sports Science Research: Investigated as a potential biomarker for assessing energy metabolism, nutrient status, and physiological stress.
• Quality Control for Clinical Labs: Used in the preparation of quality control materials to ensure the accuracy and precision of diagnostic testing platforms.

Basic Information

Product Name	2-Methylmalonoyl Carnitine
CAS No.	149181-64-6
Molecular Formula	C11H19NO6
Molecular Weight	261.27 g/mol
Synonyms	2-Methylmalonylcarnitine; (3-Carboxy-2-methylpropanoyloxy)-4-(trimethylammonio)butanoate; L-Carnitine 2-methylmalonate; 2-MMC; 2-Methylmalonyl-L-carnitine; Methylmalonylcarnitine
EINECS	Contact for details

Quality Control

We supply 2-Methylmalonoyl Carnitine as a high-purity biochemical suitable for use as a reference standard. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, impurities, and identification is provided with each shipment, supporting compliance with GMP and research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.