Description

Secretogranin Ii (154-186) (Mouse, Rat) is a defined peptide fragment corresponding to amino acids 154-186 of the mouse and rat Secretogranin II protein. This synthetic peptide is a critical research tool for studying the processing, function, and role of chromogranin/secretogranin proteins in neuroendocrine systems. It is primarily utilized by researchers in neuroscience, endocrinology, and cell biology for applications such as antibody production, immunoassay development, and functional studies of secretory granule biogenesis.

Application

• Antigen for Antibody Production: Used as an immunogen to generate polyclonal or monoclonal antibodies specific to the Secretogranin II protein region.
• Biochemical Research: Serves as a reference standard in Western blotting, ELISA, and immunohistochemistry to detect and quantify Secretogranin II expression.
• Neuroscience Studies: Employed in research investigating the role of secretogranins as precursors to bioactive peptides in neuronal and endocrine signaling.
• Cell Biology Assays: Utilized in studies of secretory pathway dynamics and granule formation within neuroendocrine cells.
• Protease Substrate: Can be used as a substrate to study the enzymatic activity of prohormone convertases involved in proprotein processing.
• Quality Control Reagent: Acts as a positive control in diagnostic assay development for neuroendocrine tumors and related conditions.

Basic Information

Product Name	Secretogranin Ii (154-186) (Mouse, Rat)
CAS No.	149146-12-3
Molecular Formula	C164H261N49O48S
Molecular Weight	~3676.2 g/mol
Synonyms	Secretogranin II (154-186); SgII (154-186); Chromogranin C (154-186); Mouse/Rat Secretogranin II Fragment; Secretoneurin Precursor Fragment; SgII Peptide; CgC (154-186); Neuroendocrine Protein Fragment 154-186
EINECS	Contact for details

Quality Control

Our Secretogranin Ii (154-186) (Mouse, Rat) is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Sequence	H-Gln-Ala-Gln-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-Glu-OH (Mouse/Rat SgII 154-186)
Single Peak on HPLC	Pass
Water Content (K.F.)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.