Description

3-Chloro-4,5-Difluoroaniline is a halogenated aniline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in introducing a difluorinated, chlorinated aniline moiety, which is essential for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in fluorinated active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluoro and chloro substituents enhance biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated compounds for electronic display materials.
• Polymer & Dye Intermediates: Employed in the synthesis of specialized dyes, pigments, and high-performance polymer additives.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) to create complex aromatic amines.

Basic Information

Product Name	3-Chloro-4,5-Difluoroaniline
CAS No.	149144-05-8
Molecular Formula	C6H4ClF2N
Molecular Weight	163.55 g/mol
Synonyms	3-Chloro-4,5-difluoroaniline; 4,5-Difluoro-3-chloroaniline; 3-Chloro-4,5-difluorobenzenamine; Benzenamine, 3-chloro-4,5-difluoro-; 149144-05-8; 3-Cl-4,5-F2-C6H2NH2
EINECS	Contact for details

Quality Control

Our 3-Chloro-4,5-Difluoroaniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.