Description

3-o-(tert-Butyldimethylsilyloxy)-2-Fmoc-Erythro-Sphingosine is a key, high-purity protected sphingosine derivative used as a critical synthetic intermediate in advanced organic and medicinal chemistry. Its primary value lies in enabling the controlled synthesis of complex sphingolipids and their analogs, which are essential for biochemical research and drug discovery. This compound is specifically designed for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality building blocks for developing novel therapeutics and investigative probes.

Application

• Sphingolipid Synthesis: A fundamental building block for the chemical synthesis of complex sphingolipids, including ceramides, sphingomyelin, and glycosphingolipids.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of novel drug candidates targeting sphingolipid-mediated pathways, such as those involved in cancer, inflammation, and neurodegenerative diseases.
• Biochemical Probe Development: Used to create labeled or modified sphingolipid analogs for studying cell signaling, membrane biology, and enzyme function in research laboratories.
• Glycoconjugate Chemistry: Facilitates the synthesis of glycosphingolipids by providing a protected sphingosine backbone ready for selective glycosylation reactions.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) studies by allowing systematic modification of the sphingosine structure to optimize biological activity and pharmacokinetic properties.

Basic Information

Product Name	3-o-(tert-Butyldimethylsilyloxy)-2-Fmoc-Erythro-Sphingosine
CAS No.	149035-77-8
Molecular Formula	C39H61NO5Si
Molecular Weight	651.99 g/mol
Synonyms	2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino-3-((tert-butyldimethylsilyl)oxy)octadec-4-ene-1-ol; Fmoc-Sphingosine TBDMS Ether; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyldimethylsilyl)-D-erythro-sphingosine; (2S,3R,4E)-2-[(Fmoc)amino]-3-[(tert-butyldimethylsilyl)oxy]-4-octadecene-1-ol; Fmoc-D-erythro-sphingosine 3-O-TBDMS ether; TBDMS-Fmoc-Sphingosine; Protected Sphingosine Derivative
EINECS	Contact for details

Quality Control

Our 3-o-(tert-Butyldimethylsilyloxy)-2-Fmoc-Erythro-Sphingosine is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive research and pharmaceutical applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.