Description

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-Cyclohexylpropanoic Acid is a high-purity, non-natural amino acid derivative protected with the 9-fluorenylmethoxycarbonyl (Fmoc) group, a cornerstone reagent in modern solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled, sequential assembly of complex peptides by providing a protected building block that is stable under standard coupling conditions yet readily cleaved under mild basic treatment. This compound is essential for research and production teams in pharmaceutical development, biotechnology, and advanced materials science who require precise, high-fidelity incorporation of a methylated, cyclohexylalanine-like residue into peptide chains.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid building block for the automated or manual synthesis of therapeutic and research peptides.
• Pharmaceutical Intermediate: For the development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetics Research: Incorporation of the cyclohexyl side chain to enhance peptide stability, modulate lipophilicity, and explore structure-activity relationships (SAR).
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Bioconjugation: As a specialized component for creating peptide-protein or peptide-small molecule conjugates with specific properties.
• Academic & Institutional Research: Fundamental studies in organic chemistry, biochemistry, and medicinal chemistry.

Basic Information

Item	Details
Product Name	(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-Cyclohexylpropanoic Acid
CAS No.	148983-03-3
Molecular Formula	C25H29NO4
Molecular Weight	407.50 g/mol
Synonyms	Fmoc-N-Me-Cyclohexylalanine; Fmoc-N-methyl-3-cyclohexyl-L-alanine; (S)-Fmoc-N-methyl-3-cyclohexylalanine; Fmoc-N-Me-Cha-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-3-cyclohexyl-L-alanine; Nα-Fmoc-Nα-methyl-3-cyclohexyl-L-alanine; N-Fmoc-N-methyl-L-3-cyclohexylalanine; Fmoc-N-methylcyclohexylalanine
EINECS	Contact for details

Quality Control

Our (S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-Cyclohexylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the exacting standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This compound is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.