Description

Fmoc-Arg(Aloc)2-Oh CAS NO 148893-34-9 is a protected derivative of the amino acid arginine, featuring both Fmoc (9-fluorenylmethoxycarbonyl) and Aloc (allyloxycarbonyl) protecting groups. This compound is critically important as a specialized building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, bioconjugates, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the sequential construction of peptide chains on resin.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs) targeting various diseases.
• Bioconjugation: Used in the preparation of peptide tags, linkers, and carriers for antibody-drug conjugates (ADCs) or diagnostic agents.
• Chemical Biology: Synthesis of custom peptides for studying protein-protein interactions, enzyme substrates, and inhibitors.
• Process Development: Serves as a critical raw material in scaling up peptide manufacturing processes under GMP conditions.
• Academic Research: Fundamental studies in organic chemistry and peptide science for novel synthesis methodologies.

Basic Information

Product Name	Fmoc-Arg(Aloc)2-Oh
CAS No.	148893-34-9
Molecular Formula	C₃₀H₃₇N₅O₈
Molecular Weight	595.65 g/mol
Synonyms	Fmoc-Arg(Aloc)2-OH; Nα-Fmoc-Nω,Nω'-bis(allyloxycarbonyl)-L-arginine; Fmoc-L-arginine(N,N'-bis(Aloc))-OH; N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N5,N5-bis(2-propen-1-yloxycarbonyl)-L-ornithine; Fmoc-Arg(Alloc)2-OH; Fmoc-Arg(Aloc)-Aloc-OH; (2S)-5-{Bis[(prop-2-en-1-yloxy)carbonyl]amino}-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid; Fmoc-Arg(Alloc)-OH (bis-Alloc protected)
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(Aloc)2-Oh is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.