Description

Alanyl-Phosphoseryl-Phosphotyrosyl-Seryl-Alanine is a synthetic, phosphorylated pentapeptide sequence of significant interest in biochemical and pharmaceutical research. This compound matters as a crucial tool for studying intracellular signaling pathways, specifically those involving tyrosine and serine phosphorylation events that regulate cell growth, differentiation, and metabolism. It is primarily needed by research institutions and biotechnology companies focused on kinase/phosphatase activity assays, antibody development, and the discovery of novel therapeutic targets for diseases like cancer and metabolic disorders.

Application

• Biochemical Research Reagent: Used as a specific substrate or inhibitor in enzymatic studies of protein kinases and phosphatases.
• Antibody Production & Validation: Serves as a critical antigen for generating and screening phospho-specific antibodies targeting the pTyr and pSer motifs.
• Cell Signaling Pathway Analysis: Employed in in vitro assays to elucidate mechanisms of signal transduction and protein-protein interactions.
• Pharmaceutical Screening: Acts as a key component in high-throughput screening (HTS) platforms to identify potential drug candidates that modulate phosphorylation-dependent pathways.
• Diagnostic Development: Utilized in the calibration and development of diagnostic assays for detecting abnormal phosphorylation states associated with diseases.
• Peptide Synthesis & Modification Studies: Provides a model compound for developing new methods in peptide synthesis, particularly for incorporating stable phosphoamino acid analogs.

Basic Information

Product Name	Alanyl-Phosphoseryl-Phosphotyrosyl-Seryl-Alanine
CAS No.	148832-06-8
Molecular Formula	C23H34N6O16P2
Molecular Weight	736.50 g/mol
Synonyms	Ala-pSer-pTyr-Ser-Ala; A-pS-pY-S-A; Phosphorylated A-S-Y-S-A Peptide; H-Ala-Ser(PO3H2)-Tyr(PO3H2)-Ser-Ala-OH; L-Alanyl-O-phospho-L-seryl-O-phospho-L-tyrosyl-L-seryl-L-alanine; pS-pY Peptide Substrate; pSer/pTyr Containing Pentapeptide; Phosphopeptide A-S-Y-S-A
EINECS	Contact for details

Quality Control

Our Alanyl-Phosphoseryl-Phosphotyrosyl-Seryl-Alanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry (MS). We provide comprehensive Certificates of Analysis (COA) detailing purity, water content, and other critical parameters to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.