Description

Fmoc-(Fmochmb)Leu-Oh is a specialized, orthogonally protected leucine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in enabling complex peptide chain assembly, particularly in the synthesis of challenging sequences where standard protection strategies fail. Pharmaceutical researchers and fine chemical manufacturers need this high-purity building block for the development of therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the Fmoc/tBu strategy, facilitating the synthesis of complex and long-chain peptides.
• Pharmaceutical Intermediate: Used in the research and production of active pharmaceutical ingredients (APIs) for peptide-based therapeutics.
• Peptidomimetic Development: Serves as a crucial component in creating modified peptide structures with enhanced stability and bioavailability.
• Bioconjugation and Labeling: Employed in the site-specific modification of peptides for diagnostic or drug delivery applications.
• Combinatorial Chemistry: Utilized in libraries for high-throughput screening to discover new lead compounds.
• Academic and Industrial Research: Essential reagent in biochemistry and medicinal chemistry laboratories for studying protein structure and function.

Basic Information

Product Name	Fmoc-(Fmochmb)Leu-Oh
CAS No.	148515-87-1
Molecular Formula	C₃₃H₃₇NO₇
Molecular Weight	559.65 g/mol
Synonyms	Fmoc-(Fmochmb)-L-leucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyloxy]-L-leucine; Fmoc-Leu(Fmochmb)-OH; Nα-Fmoc-Nε-(Fmochmb)-L-leucine; (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}{[(9H-fluoren-9-yl)methoxy]carbonyloxy}amino)-4-methylpentanoic acid; Fmoc-L-Leu(Fmochmb)-OH; Fmoc-(Fmochmb)-Leu-OH; Fmoc-(Fmochmb)Leu-OH
EINECS	Contact for details

Quality Control

Our Fmoc-(Fmochmb)Leu-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.