Description

Substance P Tfa CAS NO 148470-19-3 is a chemically modified, trifluoroacetylated (Tfa) derivative of the important neuropeptide Substance P. This derivative is a critical reagent in advanced biochemical and pharmacological research, offering enhanced stability and specific reactivity for targeted studies. It is primarily utilized by research scientists and development teams in the pharmaceutical, biotechnology, and academic sectors for neuropeptide research, receptor binding assays, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A key tool for studying the role of Substance P in pain signaling, neuroinflammation, and central nervous system disorders.
• Pharmacological Assays: Used in competitive binding and receptor activation studies to screen and characterize potential neurokinin-1 (NK1) receptor antagonists.
• Bioconjugation & Probe Development: The Tfa group serves as a protective moiety or a handle for further chemical modification to create fluorescent or affinity-labeled probes.
• Peptide Chemistry Studies: Employed in methodological research on peptide synthesis, modification, and stability under various conditions.
• Drug Discovery Platforms: Integral to high-throughput screening (HTS) campaigns targeting the Substance P pathway for new analgesics or anti-inflammatory drugs.
• Academic & Institutional Research: Supports fundamental research in physiology, cell signaling, and molecular biology within university and government laboratories.

Basic Information

Product Name	Substance P Tfa
CAS No.	148470-19-3
Molecular Formula	C78H113F3N22O21S
Molecular Weight	1768.9 g/mol
Synonyms	Substance P Trifluoroacetate Salt; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 Tfa; Neurokinin P Tfa; SP Tfa; TFA-Substance P; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 xCF3COOH
EINECS	Contact for details

Quality Control

Our Substance P Tfa is produced under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP principles for laboratory chemicals, and our quality systems are designed to meet the exacting requirements of pharmaceutical R&D and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Trifluoroacetic Acid (TFA) Content	≤ 15.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.