Description

Fradafiban CAS NO 148396-36-5 is a potent and selective non-peptide glycoprotein IIb/IIIa (GP IIb/IIIa) receptor antagonist. This compound is of significant interest in pharmaceutical research and development as a key intermediate or active pharmaceutical ingredient (API) for antiplatelet therapies. It is primarily utilized by pharmaceutical manufacturers, research institutions, and chemical suppliers engaged in the development of cardiovascular drugs and novel antithrombotic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced antiplatelet drug candidates targeting the GP IIb/IIIa receptor.
• Biochemical Research: Used as a reference standard or tool compound in pharmacological studies to investigate platelet aggregation and thrombosis mechanisms.
• Active Pharmaceutical Ingredient (API) Development: Employed in the formulation development and clinical trial material production for novel cardiovascular therapeutics.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity GP IIb/IIIa antagonists.

Basic Information

Product Name	Fradafiban
CAS No.	148396-36-5
Molecular Formula	C29H34N4O5
Molecular Weight	518.61 g/mol
Synonyms	Fradafiban; Ro 44-9883; L-703,014; 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineacetic acid, 2-[[(3S)-3-[[[4-(Aminomethyl)phenyl]amino]carbonyl]-2-oxo-1-azetidinyl]carbonyl]hydrazide; (S)-2-((2-((3-(4-(Aminomethyl)phenylcarbamoyl)-2-oxoazetidin-1-yl)-2-oxoethyl)carbamoyl)-4-guanidinophenethyl)carbamate
EINECS	Contact for details

Quality Control

Our Fradafiban is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and NMR, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.