Description

β-Amyloid (13-27) CAS NO 148270-13-7 is a defined peptide fragment of the amyloid-beta protein, a key molecule in neurological research. This high-purity synthetic peptide is essential for studying the molecular mechanisms underlying amyloid plaque formation and neurotoxicity. It is a critical research tool for neuroscientists, biochemists, and pharmaceutical developers focused on Alzheimer's disease and related neurodegenerative conditions.

Application

• Neuroscience Research: Fundamental studies on amyloid-beta aggregation kinetics, oligomer formation, and structure-activity relationships.
• Drug Discovery & Screening: Used as a target or reference standard in high-throughput assays to identify and validate potential therapeutic compounds that inhibit aggregation or promote clearance.
• Antibody & Diagnostic Development: Serves as an antigen for the production and characterization of specific antibodies used in immunoassays, ELISA kits, and imaging probes.
• Biophysical Studies: Investigation of peptide-membrane interactions, conformational changes, and fibril morphology using techniques like NMR, CD spectroscopy, and electron microscopy.
• Toxicity & Cell Biology Assays: Evaluation of the cytotoxic effects of amyloid-beta fragments on neuronal cell cultures and tissue models.
• Reference Standard: Provides a well-characterized, pure standard for quantitative analysis (e.g., HPLC, MS) in method development and quality control of related biomaterials.

Basic Information

Product Name	β-Amyloid (13-27)
CAS No.	148270-13-7
Molecular Formula	C73H113N21O22S
Molecular Weight	1620.87 g/mol
Synonyms	Amyloid β-Protein (13-27); Aβ (13-27); β-Amyloid Peptide (13-27); Amyloid β (13-27); H-HHQKLVFFAEDVGSNK-NH2; HHQKLVFFAEDVGSNK-amide; Aβ13-27
EINECS	Contact for details

Quality Control

Our β-Amyloid (13-27) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere or with desiccant.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.