Description

Cyclo(Glycyl-Prolyl-Psi(Ch2Nh)-Glycyl-Phenylalanyl-Prolyl) is a synthetic, cyclic peptide containing a reduced amide bond (psi[CH2NH]), which functions as a potent and selective protease inhibitor. This compound matters for researchers and developers in the pharmaceutical and biotechnology sectors seeking to modulate specific enzymatic pathways. It is primarily needed for advanced biochemical research, drug discovery programs, and the development of novel therapeutic agents targeting proteases involved in various disease states.

Application

• Protease Inhibition Research: Serves as a key biochemical tool for studying the mechanism and kinetics of specific proteolytic enzymes.
• Drug Discovery & Development: Used as a lead compound or reference standard in the design and screening of new protease inhibitor drugs.
• Biochemical Assay Development: Employed in the validation and calibration of high-throughput screening (HTS) assays for enzymatic activity.
• Academic & Pharmaceutical R&D: Facilitates fundamental research into cellular signaling pathways and disease mechanisms involving protease activity.
• Peptide Chemistry Studies: Acts as a model compound for investigating the structure-activity relationships (SAR) of modified peptides.

Basic Information

Product Name	Cyclo(Glycyl-Prolyl-Psi(Ch2Nh)-Glycyl-Phenylalanyl-Prolyl)
CAS No.	148138-57-2
Molecular Formula	C29H40N8O5
Molecular Weight	580.68 g/mol
Synonyms	Cyclo(Gly-Pro-psi[CH2NH]-Gly-Phe-Pro); c[Gly-Pro-psi[CH2NH]-Gly-Phe-Pro]; Reduced Amide Bond Cyclic Peptide Inhibitor; Protease Inhibitor 148138-57-2; Cyclic Hexapeptide with psi[CH2NH] linkage; GPpsiGPFP Cyclo(Gly-Pro-NH-CH2-Gly-Phe-Pro)
EINECS	Contact for details

Quality Control

Our Cyclo(Glycyl-Prolyl-Psi(Ch2Nh)-Glycyl-Phenylalanyl-Prolyl) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.