Description

Ac-Lys(Fmoc)-OH is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to provide orthogonal protection for the lysine side chain, enabling the precise and sequential construction of complex peptides. It is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled incorporation of lysine residues into peptide chains.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation and Labeling: The reactive carboxyl group and protected amine facilitate site-specific conjugation with other molecules, such as fluorophores or drug carriers.
• Antibody-Drug Conjugate (ADC) Research: Serves as a linker component or modification site in the design of targeted cancer therapies.
• Biochemical Research: Employed in studying protein-protein interactions, enzyme substrates, and as a standard in analytical method development.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.

Basic Information

Product Name	Ac-Lys(Fmoc)-OH
CAS No.	148101-51-3
Molecular Formula	C23H26N2O5
Molecular Weight	410.46 g/mol
Synonyms	Nα-Acetyl-Nε-Fmoc-L-lysine; Fmoc-Lys(Ac)-OH; Acetyl-Fmoc-lysine; N-Acetyl-N'-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine; (2S)-6-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-acetamidohexanoic acid; Nε-Fmoc-Nα-acetyl-L-lysine; Fmoc-Lys(Ac)-OH; N-Acetyl-N-ε-Fmoc-L-lysine
EINECS	Contact for details

Quality Control

Our Ac-Lys(Fmoc)-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by NMR and mass spectrometry. We provide Certificates of Analysis (COA) with every shipment, detailing all specifications and test results to ensure compliance with your research and cGMP-grade production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.5%
Specific Rotation	-15° to -20° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.