Description

Fmoc-Lys(Dnp)-Oh CAS NO 148083-64-1 is a protected amino acid derivative, specifically an Fmoc-protected lysine with a side-chain dinitrophenyl (Dnp) protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the controlled, sequential addition of lysine residues with orthogonal side-chain protection.
• Pharmaceutical Research & Development: For the synthesis of peptide drug candidates, hormones, and diagnostic agents.
• Bioconjugation & Protein Engineering: As a precursor for introducing functional handles or labels at specific lysine sites within a peptide sequence.
• Combinatorial Chemistry Libraries: Used in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: Fundamental tool for studying protein structure, function, and interactions in biochemistry and molecular biology labs.
• Production of Specialty Peptides: For the commercial-scale manufacturing of therapeutic peptides, antimicrobial peptides (AMPs), and cosmetic peptides.

Basic Information

Product Name	Fmoc-Lys(Dnp)-Oh
CAS No.	148083-64-1
Molecular Formula	C26H24N4O8
Molecular Weight	520.49 g/mol
Synonyms	Fmoc-Lys(Dnp)-OH; Nα-Fmoc-Nε-Dnp-L-lysine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-(2,4-dinitrophenyl)-L-lysine; Fmoc-Lys(Dnp)-OH; Fmoc-Lys(Dnp); Fmoc-Nε-Dnp-L-lysine; (2S)-6-[(2,4-Dinitrophenyl)amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Dnp)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles for active pharmaceutical ingredient (API) intermediates, and specifications can be tailored to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions, moisture, or light should be avoided to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-10.0° to -15.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.