Description

17-Kda Immunogen, Treponema Pallidum is a highly purified, recombinant protein antigen derived from the causative agent of syphilis. This critical reagent is essential for the development and validation of sensitive and specific diagnostic assays. It is primarily utilized by research institutions, in-vitro diagnostic (IVD) manufacturers, and biotechnology companies focused on infectious disease diagnostics and vaccine research.

Application

• Immunoassay Development: As a key coating antigen or detection target in ELISA, Western Blot, and lateral flow assays for syphilis antibody detection.
• Diagnostic Kit Production: Serves as a core component in the manufacturing of commercial diagnostic test kits for Treponema pallidum.
• Clinical Research: Used as a standard or control in serological studies to understand immune response and disease progression.
• Vaccine Research: Investigated as a potential immunogen in preclinical studies for syphilis vaccine development.
• Quality Control: Employed as a reference standard for lot-to-lot consistency testing of other diagnostic reagents.
• Antibody Specificity Testing: Used to characterize the specificity of monoclonal or polyclonal antibodies generated against T. pallidum.

Basic Information

Product Name	17-Kda Immunogen, Treponema Pallidum
CAS No.	148068-13-7
Molecular Formula	Contact for details
Molecular Weight	~17 kDa
Synonyms	17 kDa Antigen of Treponema pallidum; Tp17 Antigen; Recombinant TpN17; Treponema pallidum Membrane Protein A (TmpA); 17-kDa Lipoprotein; Syphilis Diagnostic Antigen; Treponemal Immunogen; p17 Antigen
EINECS	Contact for details

Quality Control

Our 17-Kda Immunogen is manufactured under stringent conditions to ensure batch-to-batch reproducibility and high biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, identity confirmation by immunoblotting, and functional validation in standardized immunoassays. A Certificate of Analysis (COA) detailing purity, endotoxin levels, and biological reactivity is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Upon reconstitution, aliquot and store at -70°C to -80°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure vials are equilibrated to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Identification (Immunoblot)	Reacts with specific anti-T. pallidum antisera
Purity (SDS-PAGE)	≥ 95%
Protein Content (BCA)	≥ 90% of stated weight
Endotoxin (LAL)	< 1.0 EU/µg
Solubility	Soluble in PBS or appropriate aqueous buffer
Biological Activity (ELISA)	Positive reactivity in standardized assay format

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.