Description

Preproendothelin-3 is a synthetic peptide precursor corresponding to the endothelin-3 isoform, a potent vasoconstrictor. This high-purity biochemical is essential for advanced research into cardiovascular physiology, neuroendocrine signaling, and related disease mechanisms. It serves as a critical raw material and reference standard for pharmaceutical R&D, academic institutions, and diagnostic kit manufacturers focused on endothelin pathway analysis.

Application

• Biomedical Research: Used as a key reagent in studying the biosynthesis, processing, and biological activity of endothelin-3.
• Pharmaceutical Development: Serves as a reference standard and starting material in the discovery of endothelin receptor antagonists and related therapeutics.
• Diagnostic Assays: Employed in the development and calibration of immunoassays (ELISA, RIA) for detecting endothelin peptides.
• Cell Signaling Studies: Applied in vitro to investigate the role of endothelin-3 in vasoconstriction, cell proliferation, and neural crest cell development.
• Biochemical Standardization: Acts as a purity benchmark for quality control in peptide synthesis and characterization workflows.

Basic Information

Product Name	Preproendothelin-3
CAS No.	147994-89-6
Molecular Formula	C175H277N51O53S5
Molecular Weight	4025.8 g/mol
Synonyms	PreproET-3; Endothelin-3 Precursor; Big Endothelin-3 (1-41); ET-3 (1-41); PPET3; Human Preproendothelin-3; Prepro-Endothelin 3; EDN3 Preproprotein
EINECS	Contact for details

Quality Control

Our Preproendothelin-3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.