Description

(A-C-B) Human Proinsulin is a biosynthetic precursor polypeptide to the essential hormone insulin. This high-purity intermediate is critical for research into insulin biosynthesis, diabetes pathophysiology, and the development of novel therapeutic and diagnostic approaches. It serves as a fundamental reagent for pharmaceutical R&D, academic research, and quality control in biopharmaceutical manufacturing. The product is supplied with a CAS Registry Number of 147953-50-2.

Application

• Biochemical Research: Fundamental studies on insulin folding, processing, and secretion mechanisms.
• Pharmaceutical Development: A key reference standard and starting material in the development of insulin analogs and biosimilar products.
• Diagnostic Reagent Production: Used in the development and calibration of immunoassays for measuring insulin and proinsulin levels.
• Metabolic Disease Studies: Investigating the role of proinsulin in type 1 and type 2 diabetes and metabolic syndrome.
• Cell Biology & Signaling: Research on hormone receptor interactions and intracellular signaling pathways.
• Quality Control & Validation: Serves as a critical standard for purity and identity testing in insulin manufacturing processes.

Basic Information

Product Name	(A-C-B) Human Proinsulin
CAS No.	147953-50-2
Molecular Formula	C257H383N65O77S6
Molecular Weight	~9397.8 g/mol
Synonyms	Human Proinsulin; Proinsulin Human; Insulin Precursor; Recombinant Human Proinsulin; hProinsulin; Proinsulin (human); INS Precursor; CAS 147953-50-2
EINECS	Contact for details

Quality Control

Our (A-C-B) Human Proinsulin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and biological activity, meeting the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) providing purity (typically >95% by HPLC), peptide content, and endotoxin levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content (UV)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Endotoxin (LAL)	< 10 EU/mg
Biological Activity	Assessed by immunoassay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.