Description

α-Cobratoxin (1-24) Amide is a synthetic peptide fragment derived from the neurotoxic venom of the cobra, specifically representing the N-terminal 1-24 sequence with a C-terminal amide modification. This compound serves as a critical research tool for studying the structure-activity relationships of α-neurotoxins and their specific, high-affinity interaction with nicotinic acetylcholine receptors (nAChRs). It is essential for scientists in neuroscience, pharmacology, and toxicology who require precise molecular probes to investigate receptor function, develop biosensors, or screen for potential therapeutic antagonists.

Application

• Neuroscience Research: As a selective antagonist for studying the function and distribution of muscle-type and neuronal nicotinic acetylcholine receptors.
• Pharmacological Studies: Used in competitive binding assays to characterize new drug candidates targeting the nAChR.
• Toxicology & Venom Research: A reference standard for understanding cobra venom toxicity and for the development of antivenoms.
• Biochemical Tool Development: Employed in the creation of affinity columns for receptor purification or in biosensor construction.
• Academic & Institutional R&D: Fundamental research into ion channel structure, signal transduction, and neuro-muscular junction biology.
• Diagnostic Development: Potential use in assays designed to detect specific neurotoxins or antibodies in clinical or forensic samples.

Basic Information

Product Name	α-Cobratoxin (1-24) Amide
CAS No.	147710-70-1
Molecular Formula	C₁₁₀H₁₆₈N₄₈O₃₄S₈
Molecular Weight	~2690.2 g/mol
Synonyms	α-Cobratoxin (1-24) amide; Naja kaouthia toxin (1-24) amide; Cobrotoxin fragment 1-24 amide; α-Neurotoxin (1-24), amidated; CTX (1-24)-NH₂; Short-chain neurotoxin fragment; Nicotinic acetylcholine receptor antagonist peptide; [Des-Arg2, Lys23, Tyr24]α-cobratoxin amide
EINECS	Contact for details

Quality Control

Our α-Cobratoxin (1-24) Amide is produced and tested to meet the exacting standards required for life science research. Each batch undergoes rigorous analytical characterization to ensure identity, purity, and biological activity. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and amino acid analysis. We adhere to a quality management system to guarantee batch-to-batch consistency and reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by receptor binding assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.