Description

Pyr-His-Trp-Ser-Tyr-D-Ser(Tbu)-Leu-Arg-Pro-Nhnh2 is a synthetic peptide derivative, specifically a modified analog of Gonadotropin-Releasing Hormone (GnRH). This compound is of significant value in pharmaceutical research and development due to its potential as a key intermediate or active pharmaceutical ingredient (API) in therapeutic applications. It is primarily needed by biotechnology firms, pharmaceutical manufacturers, and advanced research institutions focused on endocrinology, oncology, and reproductive medicine.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel GnRH analog therapeutics.
• Research & Development: Used in biochemical and pharmacological studies to investigate hormone-receptor interactions and signaling pathways.
• Preclinical Studies: Employed in animal models for evaluating the efficacy and pharmacokinetics of potential peptide-based drugs.
• Reference Standard: Acts as a high-purity standard for analytical method development and quality control in peptide manufacturing.
• Therapeutic Agent Development: Investigated for applications in treating hormone-dependent conditions such as prostate cancer, endometriosis, and infertility.
• Peptide Library Synthesis: Utilized in combinatorial chemistry for creating focused libraries to screen for biological activity.

Basic Information

Item	Details
Product Name	Pyr-His-Trp-Ser-Tyr-D-Ser(Tbu)-Leu-Arg-Pro-Nhnh2
CAS No.	147688-42-4
Molecular Formula	C58H84N18O14
Molecular Weight	1241.4 g/mol
Synonyms	GnRH Analog Fragment; Pyroglutamyl-Histidyl-Tryptophyl-Seryl-Tyrosyl-D-Serine(t-Butyl)-Leucyl-Arginyl-Prolyl-Hydrazide; [D-Ser(tBu)6]-GnRH(1-9) Hydrazide; LHRH Analog (1-9) Hydrazide; Gonadorelin (1-9) Hydrazide Derivative; Pyr-His-Trp-Ser-Tyr-D-Ser(O-tBu)-Leu-Arg-Pro-NHNH2; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Pyr-His-Trp-Ser-Tyr-D-Ser(Tbu)-Leu-Arg-Pro-Nhnh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and tests for residual solvents and related substances. We ensure compliance with high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.