Description

Pexiganan is a synthetic antimicrobial peptide (AMP) analog derived from magainin, a natural host defense peptide found in frog skin. This compound is significant for its broad-spectrum activity against a wide range of bacteria, including multi-drug resistant strains, and its potential to combat biofilm formation. It is primarily utilized by pharmaceutical R&D teams and manufacturers developing novel anti-infective agents, particularly for topical applications in wound care and dermatology. Pexiganan CAS NO 147664-63-9 represents a promising approach to addressing the global challenge of antibiotic resistance.

Application

• Development of novel topical antimicrobial pharmaceuticals for skin and soft tissue infections.
• Research into anti-biofilm agents for medical devices and chronic wound management.
• Active pharmaceutical ingredient (API) in formulations for diabetic foot ulcer treatments.
• Investigational use in veterinary medicine for topical infections.
• Biochemical research tool for studying the mechanism of action of antimicrobial peptides.
• Component in advanced wound dressings and hydrogel-based delivery systems.
• Potential preservative agent in niche cosmetic or dermatological preparations requiring broad-spectrum activity.

Basic Information

Product Name	Pexiganan
CAS No.	147664-63-9
Molecular Formula	C178H300N56O53
Molecular Weight	4031.6 g/mol
Synonyms	MSI-78; Locilex; Magainin analog; Magainin 2 analog; Pexiganan acetate; 22-L-Lysine-23-D-lysine-magainin-2(1-23) amide; Antimicrobial peptide MSI-78; Synthetic magainin derivative
EINECS	Contact for details

Quality Control

Our Pexiganan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency, meeting the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, purity by HPLC, and related substances. We support compliance with cGMP standards for advanced intermediates and active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content (Amino Acid Analysis)	≥ 80.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.