Description

Ac-Leu-Val-Lys-Aldehyde is a synthetic peptide aldehyde derivative, specifically designed as a potent and selective protease inhibitor. This compound is a critical research tool for studying enzyme kinetics and cellular signaling pathways, particularly those involving serine and cysteine proteases. It is essential for pharmaceutical R&D, academic research in biochemistry, and the development of novel therapeutic agents targeting proteolytic activity.

Application

• Protease Inhibition Research: Serves as a key inhibitor for mechanistic studies of serine and cysteine proteases in vitro.
• Drug Discovery & Development: Used as a lead compound or intermediate in the design of novel therapeutic agents targeting specific proteases.
• Biochemical Assay Development: Employed as a standard or control in high-throughput screening (HTS) assays to identify new enzyme inhibitors.
• Cell Biology Studies: Utilized to modulate protease activity in cell cultures to investigate their role in apoptosis, inflammation, and other cellular processes.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes studying protein biochemistry and enzymology.
• Peptide Chemistry: Acts as a specialized building block or reference standard in advanced peptide synthesis and analysis.

Basic Information

Product Name	Ac-Leu-Val-Lys-Aldehyde
CAS No.	147600-40-6
Molecular Formula	C₂₂H₄₀N₄O₅
Molecular Weight	440.58 g/mol
Synonyms	Acetyl-Leu-Val-Lys-aldehyde; N-Acetyl-L-leucyl-L-valyl-N5-[(phenylmethoxy)carbonyl]-L-ornithinal; Protease Inhibitor Ac-Leu-Val-Lys-CHO; Ac-LVK-CHO; Ac-Leu-Val-Lys-H; N-Acetyl-leucyl-valyl-lysinal; (2S)-2-Acetamido-4-methyl-N-[(2S)-3-methyl-1-[[(2S)-5-oxo-5-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-1-oxobutan-2-yl]pentanamide
EINECS	Contact for details

Quality Control

Our Ac-Leu-Val-Lys-Aldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and MS and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.