Description

4-(6-Chloro-5-Nitro-4-Pyrimidinyl)-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling the development of novel therapeutic agents. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic APIs, particularly those targeting kinase inhibition.
• Drug Discovery Research: Used in medicinal chemistry for the design and construction of novel pyrimidine-based compound libraries for biological screening.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of candidate drugs.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study specific biological pathways and protein functions.
• Agrochemical Research: Potential intermediate in the research and development of new crop protection agents.

Basic Information

Product Name	4-(6-Chloro-5-Nitro-4-Pyrimidinyl)-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	147539-23-9
Molecular Formula	C13H18ClN5O4
Molecular Weight	343.77 g/mol
Synonyms	tert-Butyl 4-(6-chloro-5-nitropyrimidin-4-yl)piperazine-1-carboxylate; 1-Boc-4-(6-chloro-5-nitro-4-pyrimidinyl)piperazine; 4-(6-Chloro-5-nitro-4-pyrimidinyl)-1-piperazinecarboxylic acid tert-butyl ester; Boc-4-(6-chloro-5-nitro-4-pyrimidinyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(6-chloro-5-nitro-4-pyrimidinyl)piperazine; 147539-23-9; 4-(6-Chloro-5-nitro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-(6-Chloro-5-Nitro-4-Pyrimidinyl)-1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.