Description

Amyloid β-Protein (25-35) Amide is a synthetic peptide fragment corresponding to residues 25-35 of the amyloid β-protein, with a C-terminal amide modification. This specific sequence is a critical region for studying the neurotoxic and aggregation properties associated with Alzheimer's disease pathology. It serves as an essential research tool for neuroscientists, biochemists, and pharmaceutical developers investigating disease mechanisms and potential therapeutic interventions.

Application

• Neuroscience Research: Fundamental studies on the aggregation kinetics, toxicity, and structural properties of amyloid beta peptides.
• Drug Discovery Screening: Used as a target or reagent in high-throughput assays to identify and validate potential inhibitors of amyloid aggregation.
• Biophysical Studies: Investigation of peptide-membrane interactions, fibril formation, and secondary structure analysis using techniques like CD spectroscopy and electron microscopy.
• Antibody Development & Validation: Acts as an antigen for the production and testing of antibodies specific to the amyloid beta protein.
• Cellular Model Studies: Induction of neurotoxicity in cultured neuronal cell lines to model aspects of Alzheimer's disease in vitro.
• Teaching & Reference Standard: Used in academic settings for advanced biochemistry and neurobiology laboratory courses.

Basic Information

Product Name	Amyloid β-Protein (25-35) Amide
CAS No.	147490-49-1
Molecular Formula	C55H86N16O15
Molecular Weight	1187.4 g/mol
Synonyms	Amyloid β-Protein (25-35) amide; Aβ25-35 amide; β-Amyloid Peptide (25-35) amide; Amyloid Beta (25-35) NH2; H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-NH2; GSNKGAIIGLM-NH2
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (25-35) Amide is manufactured under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to rigorous quality testing protocols, and custom synthesis to specific purity grades or modifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥95%
Peptide Content	≥70%
Molecular Weight	1187.4 ± 1.0 Da (by MS)
Solubility	Soluble in water, DMSO, or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.