Description

(Gln22)-Amyloid β-Protein (1-42) CAS NO 147335-12-4 is a specific, chemically defined variant of the amyloid-beta peptide, a key protein fragment in neurological research. This high-purity synthetic peptide is critical for studying the molecular mechanisms underlying Alzheimer's disease and related neurodegenerative conditions. It is an essential research-grade biochemical for academic institutions, pharmaceutical R&D laboratories, and diagnostic developers focused on neuroscience and protein aggregation.

Application

• Neuroscience Research: Fundamental studies on amyloid-beta aggregation kinetics, oligomer formation, and neurotoxicity mechanisms.
• Drug Discovery & Screening: Serving as a defined target for high-throughput screening (HTS) of potential therapeutic compounds and inhibitors of amyloid aggregation.
• Biomarker & Diagnostic Development: Use as a calibrated standard or antigen in the development of immunoassays (ELISA) and biosensors for detecting amyloid-beta isoforms.
• Structural Biology: Enabling NMR, X-ray crystallography, and cryo-EM studies to elucidate the three-dimensional structure of specific amyloid-beta variants.
• Cell Culture & In Vitro Models: Application in cellular models to induce and study amyloid-related cytotoxicity and pathway activation.
• Antibody Production & Characterization: Acting as an immunogen for generating sequence-specific antibodies or for testing antibody affinity and specificity.

Basic Information

Product Name	(Gln22)-Amyloid β-Protein (1-42)
CAS No.	147335-12-4
Molecular Formula	C203H311N55O60S
Molecular Weight	4514.0 g/mol
Synonyms	Abeta (1-42) Gln22; Aβ42 (Gln22); Amyloid β-Protein (1-42) (Gln22); Amyloid β-Peptide (1-42) with Glutamine at position 22; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; Synthetic Amyloid-β (1-42) peptide variant; β-Amyloid (1-42), Gln22-substituted
EINECS	Contact for details

Quality Control

Our (Gln22)-Amyloid β-Protein (1-42) is manufactured and tested under stringent quality systems to ensure batch-to-batch consistency and reliability for critical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to rigorous analytical standards, employing techniques such as HPLC and mass spectrometry to confirm specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This peptide is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation. Aliquot into single-use vials to minimize freeze-thaw cycles and exposure to air, as it is easily oxidized.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by amino acid analysis)
Solubility	Soluble in 1% NH₄OH or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.