Description

I Kappa B Gamma Protein is a key regulatory protein involved in the NF-κB signaling pathway, which controls cellular responses to stress, cytokines, and free radicals. This high-purity recombinant protein is essential for biochemical research, enabling the study of inflammatory responses, immune regulation, and apoptosis. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for autoimmune diseases, cancer, and chronic inflammation.

Application

• Biochemical Research: Used as a critical reagent in in vitro studies to elucidate the NF-κB signaling cascade and its role in cellular processes.
• Drug Discovery & Screening: Serves as a target protein in high-throughput screening (HTS) assays to identify potential inhibitors or modulators of the IKK complex for therapeutic development.
• Enzyme Kinetics Studies: Employed to study the phosphorylation kinetics and interaction dynamics between IκB proteins and IκB kinases (IKKs).
• Antibody Production & Validation: Acts as a pure antigen for the generation and validation of specific polyclonal or monoclonal antibodies used in diagnostic and research applications.
• Cell Signaling Pathway Analysis: Integral for reconstituting signaling pathways in cell-free systems to study the specific role of IκBγ in signal transduction.
• Academic & Educational Use: Provides a standardized protein for graduate-level research and teaching laboratories focusing on molecular biology and signal transduction.

Basic Information

Product Name	I Kappa B Gamma Protein
CAS No.	147257-52-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	NFKBIB Protein; IκBγ; IKBB Protein; Inhibitor of Nuclear Factor Kappa B Kinase Subunit Gamma; NF-κ-B Inhibitor Beta; I-κ-B-gamma; IkappaBgamma; Recombinant Human IκBγ Protein
EINECS	Contact for details

Quality Control

Our I Kappa B Gamma Protein is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity analysis by SDS-PAGE and HPLC, functional activity assays, and endotoxin level checks. Certificates of Analysis (COA) detailing all specifications are provided to guarantee the material meets the exacting standards required for sensitive research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles to maintain protein integrity and activity. Aliquot upon receipt for single-use applications.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Identification (Mass Spec)	Conforms
Biological Activity	Determined by functional assay
Endotoxin Level	< 1.0 EU/μg
Protein Content	Determined by UV absorbance
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.