Description

γ-Glutaminyl-4-Hydroxy-3-Iodobenzene is a specialized iodinated aromatic amino acid derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a crucial synthetic intermediate or reference standard for the development of novel radiopharmaceuticals and targeted molecular probes. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, oncology, and diagnostic imaging. The precise structure, featuring both a γ-glutamyl moiety and an iodophenol group, makes it valuable for studying enzyme activity and designing targeted drug conjugates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel therapeutic agents and diagnostic compounds.
• Radiopharmaceutical Precursor: Used in research for developing iodine-123 or iodine-131 labeled tracers for SPECT imaging.
• Biochemical Research: Acts as a substrate or inhibitor in studies of glutaminyl cyclase and other related enzymes.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC and LC-MS.
• Proteomics & Peptide Chemistry: Incorporated into synthetic peptides to study protein-protein interactions and post-translational modifications.
• Neuroscience Research: Investigated for its potential role in modulating neurological pathways and receptors.

Basic Information

Item	Details
Product Name	γ-Glutaminyl-4-Hydroxy-3-Iodobenzene
CAS No.	147139-63-7
Molecular Formula	C11H13IN2O5
Molecular Weight	380.14 g/mol
Synonyms	4-Hydroxy-3-iodo-L-phenylalanine, N2-(γ-L-Glutamyl)-; L-γ-Glutamyl-4-hydroxy-3-iodo-L-phenylalanine; GLHIB; Iodinated Glutamyl-Phenylalanine Derivative; (2S)-2-Amino-4-[[(1S)-1-carboxy-3-[(4-hydroxy-3-iodophenyl)amino]-3-oxopropyl]amino]-4-oxobutanoic Acid; N-γ-Glutamyl-4-hydroxy-3-iodobenzene; 3-Iodo-4-hydroxy-L-phenylalanine γ-glutamyl amide
EINECS	Contact for details

Quality Control

Our γ-Glutaminyl-4-Hydroxy-3-Iodobenzene is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.