Description

N(Alpha)-Fmoc-N(Epsilon)-Dabcyl-L-Lysine is a specialized, dual-labeled amino acid derivative designed for advanced biochemical research and development. This compound is critical for the synthesis of fluorescence resonance energy transfer (FRET)-based peptide substrates and probes, enabling real-time monitoring of enzymatic activity. It is an essential building block for researchers and manufacturers in the fields of proteomics, diagnostics, and high-throughput screening who require precise, high-purity reagents for assay development.

Application

• FRET Peptide Substrate Synthesis: Primary use in creating custom peptide substrates for monitoring protease activity (e.g., caspases, kinases, HIV protease).
• Diagnostic Assay Development: Key component in the production of fluorescent probes for clinical diagnostics and point-of-care testing devices.
• Drug Discovery & High-Throughput Screening (HTS): Used to develop sensitive assays for identifying and characterizing enzyme inhibitors in pharmaceutical research.
• Proteomics & Biochemical Research: Enables the study of protein-protein interactions and enzymatic mechanisms in real-time.
• Peptide-Based Sensor Fabrication: Integral for constructing biosensors that detect specific biological or chemical agents.
• Custom Peptide Synthesis Services: A high-value reagent for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	N(Alpha)-Fmoc-N(Epsilon)-Dabcyl-L-Lysine
CAS No.	146998-27-8
Molecular Formula	C41H43N5O6
Molecular Weight	701.82 g/mol
Synonyms	Fmoc-Lys(Dabcyl)-OH; Nα-Fmoc-Nε-Dabcyl-L-lysine; Fmoc-Lysine(Dabcyl); 5-[(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-6-{[4-({4-[(dimethylamino)phenyl]diazenyl}phenyl)amino]butanoyl)amino]hexanoic acid; Dabcyl-Lys(Fmoc)-OH; Fmoc-L-Lys(Dabcyl)-OH; FRET Amino Acid Derivative; L-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-
EINECS	Contact for details

Quality Control

Every batch of N(Alpha)-Fmoc-N(Epsilon)-Dabcyl-L-Lysine is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high purity and consistency to meet the exacting standards of research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (by HPLC), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Orange to dark red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.