Description

Fmoc-Lys(Biotin)-Oh CAS NO 146987-10-2 is a sophisticated, dual-functional amino acid derivative designed for advanced bioconjugation and peptide synthesis. This compound is critical for researchers and manufacturers requiring precise, site-specific labeling and purification of biomolecules. It is an essential building block for professionals in pharmaceutical R&D, proteomics, and the development of diagnostic assays and targeted therapeutics.

Application

• Solid-Phase Peptide Synthesis (SPPS): Used as a specialized Fmoc-protected amino acid for the controlled incorporation of biotin tags into synthetic peptides.
• Bioconjugation and Probe Development: Enables the site-specific attachment of biotin to proteins, antibodies, or other molecules for detection via streptavidin-biotin technology.
• Affinity Purification Systems: Serves as a key reagent for creating biotinylated ligands used in pull-down assays, mass spectrometry sample preparation, and protein complex isolation.
• Diagnostic Assay Manufacturing: Employed in the production of components for ELISA, lateral flow tests, and other immunoassays that utilize biotin-streptavidin amplification.
• Chemical Biology Research: Facilitates the study of protein-protein interactions, cellular localization, and signal transduction pathways through targeted labeling.
• Precision Medicine and ADC Development: Provides a versatile linker-payload component for creating targeted drug conjugates with built-in purification handles.

Basic Information

Product Name	Fmoc-Lys(Biotin)-Oh
CAS No.	146987-10-2
Molecular Formula	C31H38N4O6S
Molecular Weight	594.72 g/mol
Synonyms	Fmoc-Lys(Biotin)-OH; Nε-Biotinyl-Nα-Fmoc-L-lysine; Fmoc-Lys(Biotin)-OH; Fmoc-Nε-Biotinyl-L-lysine; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-biotinyl-L-lysine; (2S)-6-(5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanamido)-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; Fmoc-Lys(Biot)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Biotin)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.