Description

Fmoc-L-Tyr(All)-Oh is a protected derivative of the amino acid L-tyrosine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, as the Fmoc (9-fluorenylmethoxycarbonyl) group provides orthogonal protection for the α-amino function. It is an essential building block for the pharmaceutical, biotechnology, and life science research industries, enabling the synthesis of complex peptides and peptide-based therapeutics. The product is supplied as a high-purity intermediate to ensure optimal coupling efficiency and final product integrity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the Fmoc-strategy synthesis of peptides and proteins.
• Pharmaceutical Research & Development: Used in the discovery and production of novel peptide-based drugs, hormones, and diagnostic agents.
• Bioconjugation: Serves as a precursor for creating peptide tags or linkers for antibody-drug conjugates (ADCs) and other bioconjugates.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads.
• Academic & Industrial Research: Fundamental reagent for studying protein structure-function relationships, enzyme substrates, and receptor ligands.
• Production of Custom Peptides: Essential for contract research organizations (CROs) and CDMOs manufacturing peptides at various scales.

Basic Information

Item	Detail
Product Name	Fmoc-L-Tyr(All)-Oh
CAS No.	146982-30-1
Molecular Formula	C27H25NO5
Molecular Weight	443.49 g/mol
Synonyms	Fmoc-L-Tyrosine(Alloc)-OH; Fmoc-Tyr(Alloc)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[(2-propen-1-yloxy)carbonyl]-L-tyrosine; Nα-Fmoc-O-Alloc-L-tyrosine; Fmoc-Tyr(All)-OH; Fmoc-O-allyloxycarbonyl-L-tyrosine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-{[2-(prop-2-en-1-yloxy)-2-oxoethoxy]carbonyloxy}phenyl)propanoic acid; Fmoc-L-Tyrosine(O-Alloc)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-Tyr(All)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1, DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.