Description

1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(3-(((1-Methylethyl)Amino)Methyl) -1-Pyrrolidinyl)-4-Oxo-8-(Trifluoromethyl)-3-Quinolinecarboxylic Acid is a high-purity advanced pharmaceutical intermediate of significant commercial importance. This compound is a key synthetic precursor in the production of novel fluoroquinolone antibiotics, offering a critical building block for pharmaceutical R&D and manufacturing. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and active pharmaceutical ingredient (API) producers focused on next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of advanced fluoroquinolone antibiotic APIs.
• Antibacterial Drug Research: Serves as a core scaffold for medicinal chemistry programs targeting new antibacterial agents with improved efficacy and spectrum.
• Process Development: Used in route scouting, optimization, and scale-up studies for efficient API manufacturing processes.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical development.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) of quinolone derivatives.

Basic Information

Product Name	1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-(3-(((1-Methylethyl)Amino)Methyl) -1-Pyrrolidinyl)-4-Oxo-8-(Trifluoromethyl)-3-Quinolinecarboxylic Acid
CAS No.	146981-05-7
Molecular Formula	C22H25F4N3O3
Molecular Weight	455.45 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-(3-((isopropylamino)methyl)-1-pyrrolidinyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydro-3-quinolinecarboxylic acid; 8-Trifluoromethyl Quinolone Derivative; Fluoroquinolone Intermediate 146981-05-7; 7-(3-((Isopropylamino)methyl)-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic Acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-((isopropylamino)methyl)-1-pyrrolidinyl)-8-(trifluoromethyl)-3-quinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical methods including HPLC, NMR, and MS to confirm identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support our partners with the documentation necessary for their regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.