Description

Glutathione Dimethyl Ester Disulfide Dihydrochloride is a chemically modified, protected derivative of the essential antioxidant glutathione. This compound is critical for research and development where the stability and controlled reactivity of the glutathione moiety are required. It is primarily utilized by pharmaceutical researchers, biochemists, and process chemists working on drug discovery, peptide synthesis, and studies of cellular redox mechanisms.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates and prodrugs targeting oxidative stress.
• Biochemical Research: Used as a stable, cell-permeable precursor in studies of glutathione metabolism, redox signaling, and apoptosis.
• Peptide Chemistry: Acts as a protected form of glutathione for the controlled formation of disulfide bonds in peptide and protein synthesis.
• Reference Standard: Employed as an analytical standard in HPLC and LC-MS methods for quality control and metabolic studies.
• Cosmeceutical R&D: Investigated in the development of advanced skincare formulations for its potential antioxidant and anti-aging properties.
• Enzyme Studies: Utilized as a substrate or inhibitor in enzymatic assays for glutathione peroxidase and glutathione S-transferase.

Basic Information

Product Name	Glutathione Dimethyl Ester Disulfide Dihydrochloride
CAS No.	146963-33-9
Molecular Formula	C20H36Cl2N6O10S2
Molecular Weight	655.6 g/mol
Synonyms	L-Glutathione, dimethyl ester, disulfide, dihydrochloride; γ-L-Glutamyl-L-cysteinylglycine dimethyl ester disulfide dihydrochloride; GSH dimethyl ester disulfide dihydrochloride; Oxidized glutathione dimethyl ester dihydrochloride; Bis(L-glutathione dimethyl ester) disulfide dihydrochloride; NSC 328806; GSSG dimethyl ester dihydrochloride
EINECS	Contact for details

Quality Control

Our Glutathione Dimethyl Ester Disulfide Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for research and development use. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.