Description

7-(2-Aminomethylmorpholino)-1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid is a high-purity advanced pharmaceutical intermediate (API intermediate) of significant commercial importance. This compound is a key synthetic precursor in the production of modern fluoroquinolone antibiotics, valued for its structural complexity and critical role in drug synthesis. It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities engaged in the development and production of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel fluoroquinolone antibiotic active pharmaceutical ingredients (APIs).
• Antibacterial Drug Development: Used in research and development of new antibacterial compounds targeting resistant bacterial strains.
• Chemical Synthesis: Serves as a versatile intermediate for medicinal chemists to create analogs and derivatives for structure-activity relationship (SAR) studies.
• GMP Manufacturing: Supplied for use in Good Manufacturing Practice (GMP) compliant production processes for final drug substances.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in outsourced pharmaceutical development and production.

Basic Information

Product Name	7-(2-Aminomethylmorpholino)-1-Cyclopropyl-6,8-Difluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid
CAS No.	146805-34-7
Molecular Formula	C18H19F2N3O4
Molecular Weight	379.36 g/mol
Synonyms	1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-[(2-aminoethyl)morpholin-4-yl]-4-oxoquinoline-3-carboxylic acid; 7-(2-Aminoethylmorpholino)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; Quinolonecarboxylic acid derivative; Fluoroquinolone intermediate; AMC-109 intermediate; CAS 146805-34-7
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical applications. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and impurity profiling, to ensure it meets exacting customer specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support development and commercial projects with material produced under quality management systems aligned with GMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to protect the compound from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.