Description

10,11-Dihydroxy-n-(n-3-Fluoropropyl)Norapomorphine is a specialized fluorinated derivative of the aporphine alkaloid class, designed for advanced research and development. This compound is of significant interest due to its potential as a high-affinity ligand for studying dopaminergic receptor systems in neurological research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on neuroscience, neuropharmacology, and the development of novel central nervous system (CNS) therapeutics.

Application

• Neuroscience Research: Acts as a key reference standard and active pharmaceutical ingredient (API) intermediate in the study of dopamine receptor subtypes (e.g., D1, D2).
• Pharmacological Profiling: Used in in vitro and in vivo assays to investigate receptor binding affinity, selectivity, and functional activity for drug discovery programs.
• Reference Standard for Analytical Development: Serves as a high-purity calibrant for method development and validation in HPLC, LC-MS, and other analytical techniques within quality control laboratories.
• Preclinical Studies: Employed in the synthesis and evaluation of novel analogs for potential therapeutic applications in Parkinson's disease and other CNS disorders.
• Chemical Biology: Utilized as a molecular tool for probing signal transduction pathways and understanding the structure-activity relationships (SAR) of aporphine-based compounds.

Basic Information

Product Name	10,11-Dihydroxy-n-(n-3-Fluoropropyl)Norapomorphine
CAS No.	146578-65-6
Molecular Formula	C18H20FNO3
Molecular Weight	317.36 g/mol
Synonyms	N-(3-Fluoropropyl)-10,11-dihydroxynorapomorphine; 10,11-Dihydroxy-N-(3-fluoropropyl)norapomorphine; 2-Fluoroethylnorapomorphine derivative; (R)-10,11-Dihydroxy-N-(3-fluoropropyl)norapomorphine; Aporphine-10,11-diol, N-(3-fluoropropyl)-; Norapomorphine, 10,11-dihydroxy-N-(3-fluoropropyl)-; 146578-65-6; Fluoropropylnorapomorphine
EINECS	Contact for details

Quality Control

Our 10,11-Dihydroxy-n-(n-3-Fluoropropyl)Norapomorphine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with specified standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Off-white to light brown solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.