Description

4-(Trifluoromethyl)Phenyl Trifluoromethanesulfonate is a high-value trifluoromethanesulfonate (triflate) ester derivative, serving as a versatile and reactive arylating agent in advanced organic synthesis. Its core value lies in the superior leaving group ability of the triflate moiety, enabling efficient cross-coupling reactions to construct complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where the introduction of the electron-deficient 4-(trifluoromethyl)phenyl group is required for modulating biological activity or material properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylated aromatic systems.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the CF3 group enhances lipophilicity and metabolic stability.
• Cross-Coupling Reactions: An excellent electrophile in palladium-catalyzed reactions such as Suzuki, Stille, and Negishi couplings to form biaryl structures.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts.
• Material Science: Employed in the creation of monomers and polymers with specific electronic or surface properties for advanced materials.
• Chemical Research & Development: A critical reagent in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies and route scouting.

Basic Information

Product Name	4-(Trifluoromethyl)Phenyl Trifluoromethanesulfonate
CAS No.	146397-87-7
Molecular Formula	C8H4F6O3S
Molecular Weight	294.17 g/mol
Synonyms	α,α,α-Trifluoro-p-tolyl Trifluoromethanesulfonate; 4-(Trifluoromethyl)phenyl Triflate; p-(Trifluoromethyl)phenyl Triflate; 1-(Trifluoromethyl)-4-[(trifluoromethyl)sulfonyloxy]benzene; 4-Trifluoromethylphenyl Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid 4-(Trifluoromethyl)phenyl Ester; (4-Trifluoromethylphenyl) Triflate
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Phenyl Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.