Description

Activated Protein C (390-404) (Human) is a synthetic peptide fragment corresponding to a specific region of the human Activated Protein C (APC) enzyme. This high-purity reference standard is critical for research into the complex mechanisms of blood coagulation, inflammation, and cytoprotective signaling pathways. It is an essential tool for pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on thrombosis, sepsis, and novel anticoagulant therapies. CAS No. 146340-20-7.

Application

• Biochemical Research: Used as a reference standard and active component in studies of APC's serine protease activity, protein-protein interactions, and receptor binding (e.g., EPCR, PARs).
• Drug Discovery & Development: Serves as a key reagent for screening and characterizing novel anticoagulant and anti-inflammatory drug candidates targeting the Protein C pathway.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (ELISA) and activity assays designed to measure APC levels or function in clinical samples.
• Mechanistic Studies: Facilitates investigation into the cytoprotective and anti-apoptotic signaling cascades induced by APC in endothelial cells and neurons.
• Quality Control: Acts as a critical standard for the quality assurance of therapeutic proteins and biosimilars related to the Protein C system.

Basic Information

Product Name	Activated Protein C (390-404) (Human)
CAS No.	146340-20-7
Molecular Formula	C71H116N22O23S
Molecular Weight	1661.9 g/mol
Synonyms	APC (390-404); Human Activated Protein C fragment 390-404; Protein C, Activated (residues 390-404); APC Peptide; Thrombomodulin cofactor peptide; Serine protease peptide; (Human) Protein C (activated) 390-404; Recombinant APC-derived peptide
EINECS	Contact for details

Quality Control

Every batch of Activated Protein C (390-404) (Human) is manufactured and analyzed under strict quality management systems. The product undergoes rigorous testing including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all analytical results are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.